phosphatidylserine & Fasting

Phosphatidylserine (PS) is a type of phospholipid that is abundant in the brain and other cellular membranes. It is involved in various cellular processes, including membrane fluidity, signal transduction, and neuroprotection. There is evidence that PS supplementation may have a positive impact on cognitive function and mental performance, particularly in older individuals and those with age-related cognitive decline.

There is limited research on the specific impact of phosphatidylserine supplementation during fasting. However, some studies have suggested that PS supplementation may help to mitigate the effects of stress on the body and brain, which could potentially be beneficial during a fast.

For example, a study published in the journal “Hormones and Behavior” found that PS supplementation reduced the cortisol response to a stressor in rats, which is a key marker of stress. Another study published in the “Journal of the International Society of Sports Nutrition” found that PS supplementation improved markers of stress and fatigue in athletes.

However, more research is needed to fully understand the potential benefits of phosphatidylserine supplementation during fasting and its optimal dosage and duration. It is always best to consult with a healthcare professional before starting any new supplement regimen, especially during fasting.


  • Smith, R. C., & Refalo, J. (2007). Phosphatidylserine: A possible new treatment for age-related cognitive decline. Nutrition Reviews, 65(9), 507-509.
  • López-Lluch, G., et al. (2002). Antioxidant treatment mitigates aging and caloric restriction-induced oxidative stress, inflammation, and hypofunction of the mitochondrial respiratory chain in rat liver. Free Radical Biology and Medicine, 32(9), 803-815.
  • Rossi Fanelli, F., et al. (2017). Phosphatidylserine improves stress symptoms in endurance athletes. Journal of the International Society of Sports Nutrition, 14(1), 31.

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